| Osteoporosis
Evenity vs Prolia
Side-by-side clinical, coverage, and cost comparison for osteoporosis.Deep comparison between: Evenity vs Prolia with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsProlia has a higher rate of injection site reactions vs Evenity based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Prolia but not Evenity, including UnitedHealthcare
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Category
Evenity
Prolia
At A Glance
SC injection
Every month
Sclerostin inhibitor
SC injection
Every 6 months
RANKL inhibitor
Indications
- Osteoporosis
- Osteoporosis, Postmenopausal
- Osteoporosis
- Osteoporosis steroid-induced
Dosing
Osteoporosis 210 mg subcutaneously once every month for 12 doses, administered as two separate 105 mg/1.17 mL injections in the abdomen, thigh, or upper arm by a healthcare provider; supplement calcium and vitamin D during treatment.
Osteoporosis, Postmenopausal, Osteoporosis, Osteoporosis steroid-induced 60 mg as a single subcutaneous injection once every 6 months in the upper arm, upper thigh, or abdomen; all patients should receive calcium 1000 mg daily and at least 400 IU vitamin D daily.
Contraindications
- Hypocalcemia (correct pre-existing hypocalcemia prior to initiating therapy)
- History of systemic hypersensitivity to romosozumab-aqqg or any component of the product formulation, including angioedema, erythema multiforme, and urticaria
- Pre-existing hypocalcemia
- Pregnancy
- Hypersensitivity to any component of Prolia (including anaphylaxis, facial swelling, and urticaria)
Adverse Reactions
Most common (>=5%) Arthralgia, headache
Serious Major adverse cardiac events (myocardial infarction, stroke, cardiovascular death), hypersensitivity reactions (angioedema), hypocalcemia, osteonecrosis of the jaw, atypical subtrochanteric and diaphyseal femoral fractures
Most common (>=2%) Back pain, pain in extremity, musculoskeletal pain, hypercholesterolemia, cystitis
Serious Severe hypocalcemia, hypersensitivity reactions, osteonecrosis of the jaw, atypical subtrochanteric and diaphyseal femoral fractures, multiple vertebral fractures following discontinuation, serious infections, dermatologic adverse reactions
Postmarketing Anaphylaxis, rash, urticaria, facial swelling, erythema, severe symptomatic hypocalcemia, severe musculoskeletal pain, marked PTH elevation in severe renal impairment, multiple vertebral fractures following discontinuation, cutaneous lichenoid drug eruptions, alopecia, vasculitis, DRESS syndrome
Pharmacology
Sclerostin inhibitor; humanized IgG2 monoclonal antibody that increases bone formation and, to a lesser extent, decreases bone resorption by inhibiting sclerostin, a regulatory factor in bone metabolism that suppresses osteoblastic activity.
RANKL inhibitor; human IgG2 monoclonal antibody that binds RANKL, preventing RANKL/RANK interaction on osteoclasts and their precursors, thereby inhibiting osteoclast formation, function, and survival to decrease bone resorption and increase bone mass and strength in both cortical and trabecular bone.
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Most Common Insurance
Anthem BCBS
Evenity
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Prolia
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (11/12) · Qty limit (11/12)
UnitedHealthcare
Evenity
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (1/8)
Prolia
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Evenity
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Prolia
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAmgen Safety Net Foundation
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Prolia.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.