Amantadine Drug Interactions: 27 Major, 270 Moderate
Amantadine Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Amantadine. Always confirm against the full prescribing information.
100 interactions
Acetylcholine
The risk or severity of adverse effects can be increased when Amantadine is combined with Acetylcholine.
Level 2 evidence
Acyclovir
The risk or severity of adverse effects can be increased when Acyclovir is combined with Amantadine.
Level 2 evidence
Alfentanil
The risk or severity of adverse effects can be increased when Amantadine is combined with Alfentanil.
Level 1 evidence
Almotriptan
The risk or severity of serotonin syndrome can be increased when Amantadine is combined with Almotriptan.
Level 2 evidence
Amikacin
Amantadine may decrease the excretion rate of Amikacin which could result in a higher serum level.
Level 2 evidence
Amiloride
The serum concentration of Amantadine can be increased when it is combined with Amiloride.
Level 2 evidence
Amiodarone
The risk or severity of QTc prolongation can be increased when Amantadine is combined with Amiodarone.
Level 2 evidence
Amisulpride
The therapeutic efficacy of Amantadine can be decreased when used in combination with Amisulpride.
Level 2 evidence
Amitriptyline
The risk or severity of serotonin syndrome can be increased when Amitriptyline is combined with Amantadine.
Level 2 evidence
Amoxapine
The risk or severity of serotonin syndrome can be increased when Amoxapine is combined with Amantadine.
Level 2 evidence
Amphetamine
The risk or severity of serotonin syndrome can be increased when Amphetamine is combined with Amantadine.
Level 2 evidence
Anagrelide
The risk or severity of QTc prolongation can be increased when Amantadine is combined with Anagrelide.
Level 2 evidence
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Amantadine has 882 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Amantadine has 27 major, 270 moderate, and 585 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Amantadine. Always confirm against the full prescribing information.