Cotellic Drug Interactions: 238 Major, 256 Moderate
Cotellic (Cobimetinib) Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Cotellic. Always confirm against the full prescribing information.
100 interactions
Abemaciclib
The metabolism of Abemaciclib can be decreased when combined with Cobimetinib.
Level 2 evidence
Acenocoumarol
The metabolism of Acenocoumarol can be decreased when combined with Cobimetinib.
Level 2 evidence
Albendazole
The metabolism of Cobimetinib can be decreased when combined with Albendazole.
Level 2 evidence
Alectinib
The metabolism of Alectinib can be decreased when combined with Cobimetinib.
Level 2 evidence
Ambrisentan
The serum concentration of Cobimetinib can be increased when it is combined with Ambrisentan.
Level 2 evidence
Aminophylline
The metabolism of Aminophylline can be decreased when combined with Cobimetinib.
Level 2 evidence
Amiodarone
The serum concentration of Cobimetinib can be increased when it is combined with Amiodarone.
Level 1 evidence
Apalutamide
The serum concentration of Cobimetinib can be decreased when it is combined with Apalutamide.
Level 1 evidence
Apixaban
The serum concentration of Cobimetinib can be increased when it is combined with Apixaban.
Level 2 evidence
Aprepitant
The metabolism of Cobimetinib can be decreased when combined with Aprepitant.
Level 1 evidence
Armodafinil
The metabolism of Cobimetinib can be increased when combined with Armodafinil.
Level 1 evidence
Articaine
The risk or severity of methemoglobinemia can be increased when Cobimetinib is combined with Articaine.
Level 1 evidence
Enter your NPI to unlock 46 major interactions for Cotellic
Cotellic (Cobimetinib) has 527 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Cotellic (Cobimetinib) has 238 major, 256 moderate, and 33 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Cotellic. Always confirm against the full prescribing information.