Depakote Drug Interactions: 217 Major, 680 Moderate
Depakote (Divalproex Sodium) Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Depakote. Always confirm against the full prescribing information.
100 interactions
Abacavir
The metabolism of Abacavir can be decreased when combined with Valproic acid.
Level 2 evidence
Abatacept
The metabolism of Valproic acid can be increased when combined with Abatacept.
Level 1 evidence
Abiraterone
Valproic acid may increase the hepatotoxic activities of Abiraterone.
Level 2 evidence
Abrocitinib
The metabolism of Abrocitinib can be decreased when combined with Valproic acid.
Level 2 evidence
Acarbose
Acarbose may increase the hepatotoxic activities of Valproic acid.
Level 2 evidence
Acenocoumarol
The serum concentration of Acenocoumarol can be increased when it is combined with Valproic acid.
Level 1 evidence
Acetaminophen
The risk or severity of methemoglobinemia can be increased when Valproic acid is combined with Acetaminophen.
Level 2 evidence
Acetazolamide
The risk or severity of CNS depression can be increased when Valproic acid is combined with Acetazolamide.
Level 2 evidence
Acetylsalicylic acid
The metabolism of Valproic acid can be decreased when combined with Acetylsalicylic acid.
Level 1 evidence
Acitretin
Valproic acid may increase the Pseudotumor Cerebri activities of Acitretin.
Level 2 evidence
Acoramidis
The metabolism of Acoramidis can be decreased when combined with Valproic acid.
Level 2 evidence
Acrivastine
The risk or severity of QTc prolongation can be increased when Acrivastine is combined with Valproic acid.
Level 2 evidence
Enter your NPI to unlock 20 major interactions for Depakote
Depakote (Divalproex Sodium) has 1073 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Depakote (Divalproex Sodium) has 217 major, 680 moderate, and 176 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Depakote. Always confirm against the full prescribing information.