Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Mekinist. Always confirm against the full prescribing information.
100 interactions
Amikacin
Trametinib may decrease the excretion rate of Amikacin which could result in a higher serum level.
Level 2 evidence
Articaine
The risk or severity of methemoglobinemia can be increased when Trametinib is combined with Articaine.
Level 1 evidence
Benzocaine
The risk or severity of methemoglobinemia can be increased when Trametinib is combined with Benzocaine.
Level 1 evidence
Benzyl alcohol
The risk or severity of methemoglobinemia can be increased when Trametinib is combined with Benzyl alcohol.
Level 1 evidence
Bupivacaine
The risk or severity of methemoglobinemia can be increased when Trametinib is combined with Bupivacaine.
Level 1 evidence
Abacavir
Abacavir may decrease the excretion rate of Trametinib which could result in a higher serum level.
Level 2 evidence
Abatacept
Abatacept may increase the hepatotoxic activities of Trametinib.
Level 2 evidence
Abemaciclib
Trametinib may increase the hepatotoxic activities of Abemaciclib.
Level 2 evidence
Abiraterone
Abiraterone may increase the hepatotoxic activities of Trametinib.
Level 2 evidence
Acamprosate
Acamprosate may increase the hepatotoxic activities of Trametinib.
Level 2 evidence
Acarbose
Acarbose may increase the hepatotoxic activities of Trametinib.
Level 2 evidence
Acebutolol
Acebutolol may increase the hepatotoxic activities of Trametinib.
Mekinist (Trametinib) has 820 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Mekinist (Trametinib) has 1 major, 45 moderate, and 774 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Mekinist. Always confirm against the full prescribing information.