Naproxen Drug Interactions: 35 Major, 568 Moderate
Naproxen (Naproxen Sodium) Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Naproxen. Always confirm against the full prescribing information.
100 interactions
Abatacept
The metabolism of Naproxen can be increased when combined with Abatacept.
Level 1 evidence
Acebutolol
Naproxen may decrease the antihypertensive activities of Acebutolol.
Level 1 evidence
Aceclofenac
The risk or severity of adverse effects can be increased when Naproxen is combined with Aceclofenac.
Level 1 evidence
Acenocoumarol
The risk or severity of bleeding and hemorrhage can be increased when Naproxen is combined with Acenocoumarol.
Level 1 evidence
Acetylsalicylic acid
The therapeutic efficacy of Acetylsalicylic acid can be decreased when used in combination with Naproxen.
Level 1 evidence
Acoramidis
The metabolism of Naproxen can be decreased when combined with Acoramidis.
Level 2 evidence
Acyclovir
The risk or severity of nephrotoxicity can be increased when Acyclovir is combined with Naproxen.
Level 2 evidence
Adagrasib
The metabolism of Naproxen can be decreased when combined with Adagrasib.
Level 2 evidence
Adalimumab
The metabolism of Naproxen can be increased when combined with Adalimumab.
Level 1 evidence
Adefovir dipivoxil
The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Naproxen.
Level 2 evidence
Adenine
The metabolism of Naproxen can be decreased when combined with Adenine.
Level 2 evidence
Alendronic acid
The risk or severity of adverse effects can be increased when Naproxen is combined with Alendronic acid.
Level 2 evidence
Enter your NPI to unlock 3 major interactions for Naproxen
Naproxen (Naproxen Sodium) has 1138 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Naproxen (Naproxen Sodium) has 35 major, 568 moderate, and 535 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Naproxen. Always confirm against the full prescribing information.