Nucynta (Tapentadol Hydrochloride) Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Nucynta. Always confirm against the full prescribing information.
100 interactions
Acetazolamide
Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Acetazolamide.
Level 1 evidence
Alfentanil
Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
Level 1 evidence
Almotriptan
Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Almotriptan.
Level 1 evidence
Alosetron
Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Alosetron.
Level 1 evidence
Alprazolam
Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
Level 1 evidence
Alvimopan
The risk or severity of adverse effects can be increased when Tapentadol is combined with Alvimopan.
Level 1 evidence
Amisulpride
Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Amisulpride.
Level 1 evidence
Amitriptyline
Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Level 1 evidence
Amobarbital
Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Amobarbital.
Level 1 evidence
Amoxapine
Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Level 1 evidence
Apomorphine
Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Apomorphine.
Level 1 evidence
Aripiprazole
Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.
Level 1 evidence
Enter your NPI to unlock 4 major interactions for Nucynta
Nucynta (Tapentadol Hydrochloride) has 409 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Nucynta (Tapentadol Hydrochloride) has 25 major, 264 moderate, and 120 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Nucynta. Always confirm against the full prescribing information.