Otrexup Drug Interactions: 402 Major, 398 Moderate
Otrexup (Methotrexate) Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Otrexup. Always confirm against the full prescribing information.
100 interactions
5-methyltetrahydrofolic acid
The therapeutic efficacy of Methotrexate can be decreased when used in combination with 5-methyltetrahydrofolic acid.
Level 2 evidence
Abacavir
Methotrexate may increase the hepatotoxic activities of Abacavir.
Level 2 evidence
Abemaciclib
Abemaciclib may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Level 2 evidence
Abiraterone
Methotrexate may increase the hepatotoxic activities of Abiraterone.
Level 2 evidence
Acarbose
Acarbose may increase the hepatotoxic activities of Methotrexate.
Level 2 evidence
Acetazolamide
The therapeutic efficacy of Methotrexate can be increased when used in combination with Acetazolamide.
Level 1 evidence
Acyclovir
The excretion of Acyclovir can be decreased when combined with Methotrexate.
Level 2 evidence
Adefovir dipivoxil
The risk or severity of nephrotoxicity can be increased when Methotrexate is combined with Adefovir dipivoxil.
Level 2 evidence
Afatinib
Afatinib may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Level 2 evidence
Albendazole
The excretion of Methotrexate can be decreased when combined with Albendazole.
Level 2 evidence
Alectinib
Alectinib may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Level 2 evidence
Alendronic acid
The risk or severity of nephrotoxicity and hypocalcemia can be increased when Methotrexate is combined with Alendronic acid.
Level 2 evidence
Enter your NPI to unlock 28 major interactions for Otrexup
Otrexup (Methotrexate) has 1231 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Otrexup (Methotrexate) has 402 major, 398 moderate, and 431 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Otrexup. Always confirm against the full prescribing information.