Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Samsca. Always confirm against the full prescribing information.
100 interactions
Abacavir
Abacavir may increase the hepatotoxic activities of Tolvaptan.
Level 2 evidence
Abemaciclib
The serum concentration of Abemaciclib can be increased when it is combined with Tolvaptan.
Level 2 evidence
Abiraterone
Abiraterone may increase the hepatotoxic activities of Tolvaptan.
Level 2 evidence
Acarbose
Acarbose may increase the hepatotoxic activities of Tolvaptan.
Level 2 evidence
Acetylsalicylic acid
Acetylsalicylic acid may decrease the excretion rate of Tolvaptan which could result in a higher serum level.
Level 1 evidence
Acitretin
Acitretin may increase the hepatotoxic activities of Tolvaptan.
Level 2 evidence
Albendazole
The metabolism of Tolvaptan can be decreased when combined with Albendazole.
Level 2 evidence
Alfentanil
The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Alfentanil.
Level 2 evidence
Allopurinol
Allopurinol may increase the hepatotoxic activities of Tolvaptan.
Level 2 evidence
Ambrisentan
The serum concentration of Tolvaptan can be increased when it is combined with Ambrisentan.
Level 2 evidence
Aminosalicylic acid
Aminosalicylic acid may increase the hepatotoxic activities of Tolvaptan.
Level 2 evidence
Anidulafungin
Anidulafungin may increase the hepatotoxic activities of Tolvaptan.
Level 2 evidence
Enter your NPI to unlock 22 major interactions for Samsca
Samsca (Tolvaptan) has 1111 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Samsca (Tolvaptan) has 287 major, 326 moderate, and 498 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Samsca. Always confirm against the full prescribing information.