Zaleplon Drug Interactions: 75 Major, 401 Moderate
Zaleplon Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Zaleplon. Always confirm against the full prescribing information.
100 interactions
Abatacept
The metabolism of Zaleplon can be increased when combined with Abatacept.
Level 1 evidence
Acetazolamide
The risk or severity of CNS depression can be increased when Acetazolamide is combined with Zaleplon.
Level 2 evidence
Adalimumab
The metabolism of Zaleplon can be increased when combined with Adalimumab.
Level 1 evidence
Alfentanil
The risk or severity of CNS depression can be increased when Alfentanil is combined with Zaleplon.
Level 2 evidence
Almotriptan
The risk or severity of CNS depression can be increased when Almotriptan is combined with Zaleplon.
Level 2 evidence
Alosetron
The risk or severity of CNS depression can be increased when Zaleplon is combined with Alosetron.
Level 2 evidence
Alprazolam
The risk or severity of CNS depression can be increased when Alprazolam is combined with Zaleplon.
Level 2 evidence
Amikacin
Zaleplon may decrease the excretion rate of Amikacin which could result in a higher serum level.
Level 2 evidence
Aminophylline
Zaleplon may increase the excretion rate of Aminophylline which could result in a lower serum level and potentially a reduction in efficacy.
Level 2 evidence
Amisulpride
The risk or severity of CNS depression can be increased when Zaleplon is combined with Amisulpride.
Level 2 evidence
Amitriptyline
The risk or severity of CNS depression can be increased when Amitriptyline is combined with Zaleplon.
Level 2 evidence
Amobarbital
The risk or severity of CNS depression can be increased when Zaleplon is combined with Amobarbital.
Level 2 evidence
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Zaleplon has 902 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Zaleplon has 75 major, 401 moderate, and 426 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Zaleplon. Always confirm against the full prescribing information.